If a larger reactor is required, we can cool our 3,000L reactor down to -50˚C.

Hamari also has extensive experience in safely handling reagents such
as Butyl lithium, LDA, ter-BuOK, and in performing Grignard and Wittig reactions. Another strength is in our etherification process using phase transfer catalysts.

Hamari has the know how to perform Negishi Cross Coupling reactions. The production scale is 50kg in Osaka pilot plant, using a special technology to eliminate Pd down to several ppb in final product.

Click the PDF file below to view more detailed information on our Alkylation manufacturing, including:

Alkylation PDF file

• Alkyllithium (n-BuLi)
• NaH
• Tert-BuONa
• Negishi Cross Coupling (with Pd-Catalyst)
• Suzuki Coupling
• Mitsunobu Reaction