Hamari’s Past Scientific Publications

More publications. The following is a list of historical publications authored by Hamari.

Selected List of Published Research

The following is a selected list of peer-reviewed research articles authored by Hamari Chemicals, Ltd.

  1. Tandem alkylation−second-order asymmetric transformation protocol for the preparation of phenylalanine-type tailor-made α‑amino acids. ACS Omega 2018, 3, 9729–9737. DOI: 10.1021/acsomega.8b01424
  2. Second-order asymmetric transformation and its application for the practical synthesis of α-amino acids. Org. Biomol. Chem. 2018, 16, 4968–4972. DOI: 10.1039/C8OB00963E
  3. 2-Pyrrolidinecarboxamide, N-(2-Benzoyl-4-chlorophenyl)-1-[(3,4-dichlorophenyl)methyl]-,(2R)- and (2S)-. e-EROS reagent article. DOI: 10.1002/047084289X.rn02164
  4. Axially chiral Ni(II) complexes of α‐amino acids: Separation of enantiomers and kinetics of racemization. Chirality 2018, 30, 498–508. DOI: 10.1002/chir.2281
  5. Identification of novel plasminogen activator inhibitor-1 inhibitors with improved oral bioavailability: Structure optimization of N-acylanthranilic acid derivatives. Bioorg. Med. Chem. Lett. 2018, 28, 809–813. DOI: 10.1016/j.bmcl.2017.11.016
  6. 健康成人男性におけるモンテルカストチュアブル錠5 mg「AA」/「アスペン」/「オーハラ」の生物学的同等性試験. 臨床医薬 2017, 33, 5, 443–468. ISSN: 0910-8211
  7. An N-protection free ligation of the peptide thioester and the peptide with an N-alkoxy- or N-aryloxyamino group at its N-terminus. Tetrahedron Lett. 2017, 58, 4638–4641. DOI: 10.1016/j.tetlet.2017.10.074
  8. Analysis of crystallographic structures of Ni(II) complexes of α-amino acid Schiff bases: Elucidation of the substituent effect on stereochemical preferences. Dalton Trans. 2017, 46, 4191–4198. DOI: 10.1039/C7DT00014F
  9. Operationally convenient and scalable asymmetric synthesis of (2S)- and (2R)-α-(methyl)cysteine derivatives through alkylation of chiral alanine schiff base NiII complexes Eur. J. Org. Chem. 2017, 14, 1931–1939. DOI: 10.1002/ejoc.201700018
  10. Scale-up synthesis of (R)- and (S)-N-(2-Benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl) pyrrolidine-2-carboxamide hydrochloride, a versatile reagent for the preparation of tailor-made α- and β-amino acids in an enantiomerically pure form. Org. Process Res. Dev. 2017, 21, 732–739. DOI: 10.1021/acs.oprd.7b00055
  11. Recent approaches for asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes. Amino Acids 2017, 49, 1487–1520. DOI: 10.1007/s00726-017-2458-6
  12. Asymmetric synthesis of α-deuterated α-amino acids. Org. Biomol. Chem. 2017, 15, 6978–6983. DOI: 10.1039/C7OB01720K
  13. Unprecedented property of 4,6-di(substituted)amino-1,2-dihydro-1,3,5-triazines: Formation of acid salts by simple treatment with alkali metal salts of protic acids. Bull. Chem. Soc. Jpn. 2017, 90, 178–187. DOI: 10.1246/bcsj.20160329
  14. Purely chemical approach for preparation of D-α-amino acids via (S)-to-(R)-interconversion of unprotected tailor-made α-amino acids. J. Org. Chem. 2016, 81, 3501–3508. DOI: 10.1021/acs.joc.5b02707
  15. Asymmetric synthesis of aromatic and heteroaromatic α-amino acids using a recyclable axially chiral ligand. Eur. J. Org. Chem. 2016, 5, 999–1006. DOI: 10.1002/ejoc.201501442
  16. Advanced asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid by alkylation/cyclization of newly designed axially chiral Ni(II) complex of glycine Schiff base. Amino Acids 2016, 48, 973–986. DOI: 10.1007/s00726-015-2138-3
  17. Recyclable ligands for the non-enzymatic dynamic kinetic resolution of challenging α-amino acids. Angew. Chem. Int. Ed. 2015, 54, 12918–12922. DOI: 10.1002/anie.201507273
  18. Chemical dynamic thermodynamic resolution and S/R interconversion of unprotected unnatural tailor-made α-amino acids. J. Org. Chem. 2015, 80, 9817–9830. DOI: 10.1021/acs.joc.5b01292
  19. Asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid by sequential SN2–SN2’ dialkylation of (R)-N-(benzyl)proline-derived glycine Schiff base Ni(II) complex. RSC Adv. 2015, 5, 1051–1058. DOI: 10.1039/C4RA12658K
  20. Synthesis of (2S,3S)-β-(trifluoromethyl)-α,β-diamino acid by Mannich addition of glycine Schiff base Ni(II) complexes to N–tert-butylsulfinyl-3,3,3-trifluoroacetaldimine. J. Fluorine Chem. 2015, 171, 67–72. DOI: 10.1016/j.jfluchem.2014.09.013
  21. Chemical dynamic kinetic resolution and S/R interconversion of unprotected α-amino acids. Angew. Chem. Int. Ed. 2014, 53, 12214–12217. DOI: 10.1002/anie.201407944
  22. Flavin-catalyzed aerobic oxidation of sulfides and thiols with formic acid/triethylamine. Chem. Commun. 2014, 50, 10295–10298. DOI: 10.1039/C4CC05216A
  23. Design and synthesis of (S)- and (R)-α-(phenyl)ethylamine-derived NH-type ligands and their application for the chemical resolution of α-amino acids. Org. Biomol. Chem. 2014, 12, 6239–6249. DOI: 10.1039/C4OB00669K
  24. Asymmetric synthesis of α-amino acids under operationally convenient conditions. Adv. Synth. Catal. 2014, 356, 2203–2208. DOI: 10.1002/adsc.201400405
  25. Asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes of glycine Schiff bases. Part 3: Michael addition reactions and miscellaneous transformations. Amino Acids 2014, 46, 2047–2073. DOI: 10.1007/s00726-014-1764-5
  26. Inexpensive chemical method for preparation of enantiomerically pure phenylalanine. Amino Acids 2014, 46, 945–952. DOI: 10.1007/s00726-013-1656-0
  27. Synthesis and stereochemical assignments of diastereomeric Ni(II) complexes of glycine Schiff base with (R)-2-(N-{2-[N-alkyl-N-(1-phenylethyl)amino]acetyl}amino)benzophenone; A case of configurationally stable stereogenic nitrogen. Beilstein J. Org. Chem. 2014, 10, 442–448. DOI: 10.3762/bjoc.10.41
  28. NH-type of chiral Ni(II) complexes of glycine Schiff base: design, structural evaluation, reactivity and synthetic applications. Org. Biomol. Chem. 2014, 12, 1278–1291. DOI: 10.1039/C3OB41959B
  29. Asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes of glycine Schiff bases. Part 2: Aldol, Mannich addition reactions, deracemization and (S) to (R) interconversion of α-amino acids. Amino Acids 2013, 45, 1017–1033. DOI: 10.1007/s00726-013-1580-3
  30. Asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes of glycine Schiff bases; Part 1: alkyl halide alkylations. Amino Acids 2013, 45, 691–718. DOI: 10.1007/s00726-013-1539-4
  31. Chemical deracemization and (S) to (R) interconversion of some fluorine-containing α-amino acids. J. Fluorine Chem. 2013, 152, 114–118. DOI: 10.1016/j.jfluchem.2013.02.022
  32. Synthesis of bis-α,α’-amino acids through diastereoselective bis-alkylations of chiral Ni(II)-complexes of glycine. Org. Biomol. Chem. 2013, 11, 4508–4515. DOI: 10.1039/C3OB40594J
  33. Chemical approach for interconversion of (S)- and (R)-α-amino acids. Org. Biomol. Chem. 2013, 11, 4503–4507. DOI: 10.1039/C3OB40541A
  34. Plasminogen activator inhibitor-1阻害薬 Current Therapy 2011, 29, 70-73. ISSN: 02878445
  35. Structure-Activity Relationships of New N-Acylanthranilic Acid Derivatives as Plasminogen Activator Inhibitor-1 Inhibitors. Chem. Pharm. Bull. 2011, 59, 215–224. DOI: 10.1248/cpb.59.215
  36. Effect of Carnosine and its Trolox-Modified Derivatives on Life Span of Drosophila melanogaster. Rejuvenation Res. 2010, 13, 453–457. DOI: 10.1089/rej.2009.1010
  37. Structure–Activity Relationships of New 2-Acylamino-3-thiophenecarboxylic Acid Dimers as Plasminogen Activator Inhibitor-1 Inhibitors. Chem. Pharm. Bull. 2010, 58, 615–619. DOI: 10.1248/cpb.58.615
  38. Bactericidal Effect of HM-242, a Novel Disinfectant, against Pseudomonas aeruginosa. Biocontrol Sci. 2010, 15, 7–13. DOI: 10.4265/bio.15.7
  39. A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates.  J. Cereb. Blood Flow Metab. 2010, 30, 904–912. DOI: 10.1038/jcbfm.2009.272
  40. Biological Activity of Novel Synthetic Derivatives of Carnosine.  Cell. Mol. Neurobiol. 2010, 30, 395–404. DOI: 10.1007/s10571-009-9462-7
  41. Synthesis of Novel 4,6-Di(substituted)amino-1,2-dihydro-1,3,5-triazine Derivatives as Topical Antiseptic Agents. J. Med. Chem. 2009, 52, 597–600. DOI: 10.1021/jm8014712
  42. In vitro evaluation of the antimicrobial activity of HM-242, a novel antiseptic compound. J. Antibiot. 2009, 62, 489–493. DOI: 10.1038/ja.2009.56
  43. A New Synthetic Method of Zinc(II) Complexes Based on Mixing.  Yakugaku Zasshi 2005, 125, 829–832. DOI: 10.1248/yakushi.125.829
  44. L-Carnosine and Close Derivatives Accelerate Zinc Uptake from the lntestine in Rats.  Biomed.Res.Trace.Elements. 2001, 12, 159–167. ISSN: 1880-1404
  45. Characterization of Crystalline L-carnosine Zn(II) Complex (Z-103), a Novel Anti-gastric Ulcer Agent: Tautomeric Change of Imidazole Moiety upon Complexation. Chem. Pharm. Bull. 1990, 38, 2140–3146. DOI: 10.1248/cpb.38.3140
  46. A simple ring-expansion of 1,4-benzothiazines to give 1,5-benzothiazepines. J. CHEM. SOC., CHEM. COMMUN. 1983, 8, 450–451. DOI: 10.1039/C39830000450